REPRESSION OF THE VALINE-ISOLEUCINE PATHWAY IN SALMONELLA
نویسندگان
چکیده
منابع مشابه
Isoleucine - Valine Requiring Mutants of Salmonella Typhimurium
E have isolated a number of mutant strains of Salmonella typhimurium that display a marked inhibition of growth when valine is added to minimal medium. Attempts to elucidate the nature of the mutation(s) in these valinesensitive strains have included enzymatic and transductional analyses, as well as growth studies, on four of these strains. The results of these studies are presented and discuss...
متن کاملIsoleucine-valine Requiring Mutants of Salmonella Typhimurium.
initial reports on the mutant strains of Salmonella typhimurium that T: eui r both isoleucine and valine for growth (ilva strains) were published concomitantly by GLANVILLE and DEMEREC ( 1960) and WAGNER and BERGQUIST (1960). These studies showed that although the available ilva strains could be divided into four complementation groups ( A , B , C and D ) on the basis of abortive transduction r...
متن کاملMultivalent repression of isoleucine- valine biosynthesis in Saccharomyces cerevisiae.
Regulation of the biosynthesis of four of the five enzymes of the isoleucine-valine pathway was studied in Saccharomyces cerevisiae. A method is described for limiting the growth of a leucine auxotroph by using valine as a competitor for the permease. Limitation for isoleucine and valine was accomplished by the use of peptides containing these amino acids conjugated with glycine as nutritional ...
متن کاملGenetic Blocks in the Isoleucine-valine Pathway of Neurospora Crassa.
A group of mutants of Neurospora crassa which require both isoleucine and valine have been described in a series of previous communications from this laboratory (WAGNER, SOMERS and BERGQUIST 1960; WAGNER, KIRITANI and BERGQUIST 1962; and KIRITANI 1962). These mutants were all found to be closely linked between the linkage group V markers Zys-1 (lysine-1, 33933) and sp (spray) within a segment a...
متن کاملControl of isoleucine, valine, and leucine biosynthesis. I. Multivalent repression.
Repression of the formation of biosynthetic enzymes by the ultimate end product of their action has been shown to be an important aspect of metabolic regulation in microorganisms.1 In Escherichia coli and Salmonella typhimuwium each of the last four steps in the synthesis of valine and isoleucine is catalyzed by the same enzymes.2 Repression of these enzymes presents a unique situation since tw...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1963
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.49.5.628